Skin Sensitization Testing in Potency and Risk Assessment
نویسندگان
چکیده
منابع مشابه
Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data.
In this paper, we propose a quantitative risk assessment methodology for skin sensitization aiming at the derivation of 'safe' exposure levels for sensitizing chemicals, used e.g., as ingredients in consumer products. Given the limited number of sensitizers tested in human sensitization tests, such as the human repeat-insult patch test (HRIPT) or the human maximization test (HMT), we used EC3 v...
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The paper provides an overview of existing Integrated Testing Strategies (ITS) for assessing hazard and potency of skin sensitization. The ITS research is active, diverse and constantly evolving as new assays are being developed and new mechanistic insights are discovered. Despite the need to assess potency, the majority of the ITS approaches developed to date assess hazard only. Reasons for th...
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Anne Marie Api Research Institute for Fragrance Materials, Inc. (RIFM), Woodcliff Lake, New Jersey, USA J.H.E. Arts TNO Quality of Life, Zeist, Netherlands Harmonization Project Document No. 5 4 David Basketter Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedford, United Kingdom Jonathan Chen Antimicrobials Division, Office of Pesticide Programs, Environmental Protection Agen...
متن کاملPrediction of skin sensitization potency using machine learning approaches.
The replacement of animal use in testing for regulatory classification of skin sensitizers is a priority for US federal agencies that use data from such testing. Machine learning models that classify substances as sensitizers or non-sensitizers without using animal data have been developed and evaluated. Because some regulatory agencies require that sensitizers be further classified into potenc...
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BACKGROUND The development of non-animal alternatives for skin sensitization potency prediction is dependent upon the availability of a sufficient dataset whose human potency is well characterized. Previously, establishment of basic categorization criteria for 6 defined potency categories, allowed 131 substances to be allocated into them entirely on the basis of human information. OBJECTIVES ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2001
ISSN: 1096-0929
DOI: 10.1093/toxsci/59.2.198